Selected Publications

K Fernando, HS Quah, L Suteja, A James, FF Kuthubudeen, KZ Wu, C Adine, H Bhuvaneswari, S Selvarajan, **NG Iyer**, ELS Fong. Extended human lymph node explants for evaluation of adaptive immunity. Trends Biotechnol. 2025 Aug.
pmid: 40885665; doi: 10.1016/j.tibtech.2025.07.020

G Raj, M Raj, HHM Ng, J Suh, NB Shannon, RH Nagadia, **NG Iyer**, AR Dharmawan. Outcomes of an Enhanced Recovery After Surgery (ERAS) protocol following head and neck surgery with free flap reconstruction. Int J Oral Maxillofac Surg. 2025 Aug.
pmid: 40850850; doi: 10.1016/j.ijom.2025.08.005

Y Wang, Z Zhao, NCW Ho, **NG Iyer**, ELS Fong. Interplay between matrix viscoelasticity and integrin engagement modulates cancer-associated fibroblast plasticity. Adv Healthc Mater. 2025 Aug.
pmid: 40726283; doi: 10.1016/j.ijom.2025.08.005

ELL Yeo, BH Hong, SH Tay, J Neo, EHW Ong, WM Chow, KM Tan, KP Low, AYL Sim, T Lu, X Zhang, L Huang, JSH Tan, JTS Wee, YL Soong, KW Fong, TWK Tan, SY Sin, XX Sam, JSG Hwang, TKH Lim, JYJ Lee, LH Loo, KC Soo, **NG Iyer**, KS Loh, JK Tay, J Liu, MK Ang, JPS Yeong, JX Bei, SH Tan, DWT Lim, MLK Chua. Tumor immune microenvironment delineates distinct clinical phenotypes of nasopharyngeal carcinoma. Cell Rep Med. 2025 Jun.
pmid: 40412382; doi: 10.1016/j.xcrm.2025.102143

Y Sun, H Wang, ... , **NG Iyer**, Z Liu, Y Zhu, H Guan, T Guo. A protein-based classifier for differentiating follicular thyroid adenoma and carcinoma. EMBO Mol Med. 2025 Jul.
pmid: 40442320; doi: 10.1038/s44321-025-00242-2

KZ Wu, RH Ding, Z Zhao, CYL Chong, R You, H Zhou, DH Seah, WQ Leow, HK Lim, S Shyamasundari, K Fernando, FF Kuthubudeen, G Ng, CY Tay, **NG Iyer**, CAJ Ong, ELS Fong. Hydrogel-Mediated Preservation of Live Tumor Explants for Drug Development in Peritoneal Metastases. Adv Mater. 2025 May.
pmid: 40391640; doi: 10.1002/adma.202418647

S Chia, JJW Seow, ... , **NG Iyer**, R DasGupta. CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. Cell Rep Med. 2025 Apr.
pmid: 40187357; doi: 10.1016/j.xcrm.2025.102053

Y Chen, NM Davidson, ... , **NG Iyer**, SG-NEx consortium. A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell lines. Nat Methods. 2025 Mar.
pmid: 40082608; doi: 10.1038/s41592-025-02623-4

Widjaja W, Ng I, Shannon N, **NG Iyer**. Neoadjuvant immunotherapy in resectable HNSCC: an updated systematic review and meta-analysis. Ann Surg Oncol. 2025 Dec.
pmid: 39645552; doi: 10.1245/s10434-024-16587-w

Lai YT, Peh HY, Abdul Kadir HB, Lee CF, **NG Iyer**, Wong TH, Tay GCA. Bioelectrical impedance analysis in perioperative nutritional assessment. OTO Open. 2025 Jan.
pmid: 39759946; doi: 10.1002/oto2.70046

NB Shannon, **NG Iyer**, MLK Chua. Leveraging AI and radiomics for nasopharyngeal carcinoma prognostication. Cancer Med. 2025 Mar.
pmid: ; doi: 10.1002/cam4.70706

He F, Aebersold R, ... , **NG Iyer**. π-HuB: The proteomic navigator of the human body. Nature. 2024 Dec.
pmid: 39663494; doi: 10.1038/s41586-024-08280-5

Lim WK, **NG Iyer**. A GD (Gamma-Delta) type of cancel culture. Immunooncol Technol. 2024 Dec.
pmid: 39717204; doi: 10.1016/j.iotech.2024.100740

Widjaja W, Shannon NB, **NG Iyer**. Neoadjuvant immunotherapy in HNSCC systematic review. Ann Surg Oncol. 2024 Dec.
pmid: ; doi: 10.1245/s10434-024-16587-w

Mitriashkin A, Ho NCW, **NG Iyer**, Fong ELS. Cell confinement induces CAF phenotype changes. Acta Biomater. 2024 Dec.
pmid: ; doi: 10.1016/j.actbio.2024.12.007

Toh SY, Leong HS, ... , **NG Iyer**. Extracellular vesicle EGFR isoform D therapy. Dev Cell. 2024 Jul.
pmid: 39089249; doi: 10.1016/j.devcel.2024.07.003

Tan QX, Shannon NB, ... , **NG Iyer**, Ong CJ. Transcriptomic convergence in field cancerization. Front Oncol. 2024 Jun.
pmid: 38939336; doi: 10.3389/fonc.2024.1272432

Shannon NB, **NG Iyer**. Lymph as HPV marker in OPSCC. Clin Cancer Res. 2024 Jan.
pmid: 38252056; doi: 10.1158/1078-0432.CCR-23-3549

Ho NCW, Wang Y, ... , **NG Iyer**, Fong ELS. Hydrogels recapitulate fibroblast heterogeneity. Adv Sci. 2024 Mar.
pmid: 38493497; doi: 10.1002/advs.202307129

Adine C, Fernando K, ... , **NG Iyer**, Fong ELS. Hydrogel tumor explant preservation for drug testing. Biomaterials. 2024 Mar.
pmid: 38246018; doi: 10.1016/j.biomaterials.2023.122460

Subramaniam N, Clark JR, ... , **NG Iyer**. Improving nodal staging in oral cancer. Surg Oncol. 2024 Jan.
pmid: 38211447; doi: 10.1016/j.suronc.2024.102033

Singh M, Thankappan K, ... , **NG Iyer**. Young onset oral cancer burden analysis. Cancer Med. 2024 Feb.
pmid: 38225902; doi: 10.1002/cam4.6747

Tan JSH, Ong EHW, ... , **NG Iyer**. Radiotherapy + pembrolizumab in anaplastic thyroid cancer. Eur Thyroid J. 2024 Jan.
pmid: 38181007; doi: 10.1530/ETJ-23-0144

Wu KZ, Adine C, ... , **NG Iyer**, Fong ELS. Making in vitro tumor models whole again. Adv Healthc Mater. 2023 Jun.
pmid: 36718949; doi: 10.1002/adhm.202202279

Lim DW, Kao HF, ... , **NG Iyer**. Dual PD-1/CTLA-4 blockade in NPC. Nat Commun. 2023 May.
pmid: 37188668; doi: 10.1038/s41467-023-38407-7

Quah HS, Cao EY, ... , **NG Iyer**. Single cell immune evasion in head and neck cancer. Nat Commun. 2023 Mar.
pmid: 36973261; doi: 10.1038/s41467-023-37379-y

Peres MA, Huihua L, ... , **NG Iyer**. HPV-related cancer trends Singapore 1968–2017. Oral Oncol. 2023 Jan.
pmid: 36516662; doi: 10.1016/j.oraloncology.2022.106272

Liu WN, So WY, ... , **NG Iyer**. CAR-NK + nivolumab in humanized model. Sci Adv. 2022 Nov.
pmid: 36417514; doi: 10.1126/sciadv.add1187

Sun Y, Selvarajan S, ... , **NG Iyer**, Guo T. AI-based thyroid nodule classification. Cell Discov. 2022 Sep.
pmid: 36068205; doi: 10.1038/s41421-022-00442-x

Linn YL, Khoo MSQ, ... , **NG Iyer**. Frey syndrome meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Jul.
pmid: 35431179; doi: 10.1016/j.oooo.2021.12.123

Kao NH, **NG Iyer**. Post-op QoL in head and neck cancer. Support Care Cancer. 2022 May.
pmid: 35119518; doi: 10.1007/s00520-022-06871-4

Sun Y, Li L, ... , **NG Iyer**. Proteomic stratification of follicular thyroid tumors. Mol Oncol. 2022 Apr.
pmid: 35194950; doi: 10.1002/1878-0261.13198

Goh KY, ... , **NG Iyer**. Matrisomal genes in HNSCC and cetuximab response. Cancer Commun. 2022 Apr.
pmid: 35234368; doi: 10.1002/cac2.12279

Singh M, ... , **NG Iyer**. Adverse features in oral cancer staging. Head Neck. 2022 Apr.
pmid: 35102642; doi: 10.1002/hed.26990

Teng YHF, Quah HS, ... , **NG Iyer**. TCR clonotypes in tumor microenvironment. Cancer Immunol Immunother. 2022 Apr.
pmid: 34580764; doi: 10.1007/s00262-021-03047-7

Fong ELS, **NG Iyer**. Next generation in vitro tumor models. Adv Drug Deliv Rev. 2021 Dec.
pmid: 34763000; doi: 10.1016/j.addr.2021.114047

Chua KP, Teng YHF, ... , **NG Iyer**. EGFR-mutant NSCLC lineage transition. Clin Cancer Res. 2021 Nov.
pmid: 34261696; doi: 10.1158/1078-0432.CCR-20-4607

Belotti Y, Lim SB, **NG Iyer**. Matrisomal gene prognostic panel. Cancers. 2021 Nov.
pmid: 34830910; doi: 10.3390/cancers13225761

Tang LJW, Zaseela A, ... , **NG Iyer**. Engineering stromal heterogeneity. Adv Drug Deliv Rev. 2021 Aug.
pmid: 34087326; doi: 10.1016/j.addr.2021.05.027

Too NSH, Ho NCW, ... , **NG Iyer**. Immune contextures in tumor models. Adv Drug Deliv Rev. 2021 Aug.
pmid: 33965462; doi: 10.1016/j.addr.2021.05.001

Oh LJ, Asher R, ... , **NG Iyer**. Age and gender in oral SCC. Oral Oncol. 2021 May.
pmid: 33618102; doi: 10.1016/j.oraloncology.2021.105210

Rangabashyam M, Koh SQ, ... , **NG Iyer**. Return to work in head and neck cancer survivors. Head Neck. 2021 May.
pmid: 33599355; doi: 10.1002/hed.26644

Neo WL, Ng JCF, **NG Iyer**. Bell’s palsy and SARS-CoV-2 case report. Clin Case Rep. 2021 Mar.
pmid: 33768805; doi: 10.1002/ccr3.3716

Oh LJ, Satgunaseelan L, ... , **NG Iyer**. Young age not predictor of survival in oral cancer. Oral Oncol. 2021 Apr.
pmid: 33548861; doi: 10.1016/j.oraloncology.2020.105162

Low JL, Lau DP, ... , **NG Iyer**. Aurora kinase target in HNSCC drug resistance. EBioMedicine. 2021 Feb.
pmid: 33529999; doi: 10.1016/j.ebiom.2021.103220

Seet AOL, Tan AC, ... , **NG Iyer**. IMPACT-SG molecular profiling study. JCO Precis Oncol. 2021.
pmid: 34250396; doi: 10.1200/PO.20.00261

Bottino LZMF, Rodrigues-Junior DM, ... , **NG Iyer**. EV inhibition of inflammasomes. Curr Res Immunol. 2021.
pmid: 35492395; doi: 10.1016/j.crimmu.2021.10.005

Wong RLY, Wong MRE, ... , **NG Iyer**. Neuroblastoma genomic profiling and drug response. Front Oncol. 2021.
pmid: 34722256; doi: 10.3389/fonc.2021.709525

WL Neo, JCF Ng, NG Iyer. The great pretender—Bell’s palsy secondary to SARS-CoV-2?. Clin Case Rep. 2021 Feb 12;9(3):1175-1177.
pmid: ; doi: 10.1002/ccr3.3716

JL Low, DP Lau, X Zhang, XL Kwang, N Rohatgi, JV Chan, HS Leong, S Rikka, DSW Tan, G Periyasamy, JLY Koh, NG Iyer, R DasGupta. A chemical genetic screen identifies Aurora kinases as therapeutic targets in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma. EBioMedicine. 2021 Jan 30;64:103220.
pmid: ; doi: 10.1016/j.ebiom.2021.103220

LJ Oh, L Satgunaseelan, R Asher, M Veness, R Smee, D Goldstein, NG Iyer, D Balasubramanian, H Low, CE Palme, R Gupta, JR Clark. Young age is not a predictor of disease-specific survival in oral cancer: A multi-institutional study. Oral Oncol. 2021;115:105162.
pmid: ; doi: 10.1016/j.oraloncology.2020.105162

N Subramaniam, JR Clark, D Goldstein, J de Almeida, AHA Abdalaty, D Balasubramanian, K Thankappan, S Iyer, M Batstone, NG Iyer, RI Smee, NH Chandrasekhar, V Pillai, V Shetty, V Rangappa, M Veness, TH Low. Geographical heterogeneity in the American Joint Committee on Cancer oral cancer staging and prognostic implications. Oral Oncol. 2020;113:105122.
pmid: ; doi: 10.1016/j.oraloncology.2020.105122

J Perry, BG Ashford, AS Thind, ME Gauthier, E Minaei, G Major, NG Iyer, R Gupta, JR Clark, M Ranson. Comprehensive mutational and phenotypic characterization of new metastatic cutaneous squamous cell carcinoma cell lines reveal novel drug susceptibilities. Int J Mol Sci. 2020;21(24):E9536.
pmid: ; doi: 10.3390/ijms21249536

AHY Chew, N Chandramouli, R Kanesvaran, NG Iyer, WYK Hwang. Winning the war against cancer. Ann Acad Med Singapore. 2020;49(10):779-788.
pmid: ; doi:

BR Campbell, Z Chen, DL Faden, N Agrawal, GJ Hanna, NG Iyer, SG Rozen, A Boot, AL Vettore, B Panda, NM Krishnan, CR Pickering, JN Myers, X Guo, KAL Kuhs. The mutational landscape of early and typical onset oral tongue squamous cell carcinoma. Cancer. 2020 Nov.
pmid: ; doi: 10.1002/cncr.33309

F Zhang, S Yu, L Wu, Z Zang, X Yi, J Zhu, C Lu, P Sun, Y Sun, S Selvarajan, L Chen, X Teng, Y Zhao, G Wang, J Xiao, S Huang, OL Kon, NG Iyer, SZ Li, Z Luan, T Guo. Phenotype Classification using Proteome Data in a Data-Independent Acquisition Tensor Format. J Am Soc Mass Spectrom. 2020.
pmid: ; doi: 10.1021/jasms.0c00254

SM Lek, K Li, QX Tan, NB Shannon, WH Ng, J Hendrikson, JWS Tan, HJ Lim, Y Chen, KKN Koh, T Skanthakumar, XL Kwang, FT Chong, HS Leong, G Tay, NE Putri, TKH Lim, JSG Hwang, MK Ang, DSW Tan, NC Tan, HK Tan, OL Kon, KC Soo, NG Iyer, CAJ Ong. Pairing a Prognostic Target with Potential Therapeutic Strategy for Head and Neck Cancer. Oral Oncol. 2020;111:105035.
pmid: ; doi: 10.1016/j.oraloncology.2020.105035

KLM Chua, M Fehlings, ELL Yeo, A Nardin, H Sumatoh, PL Chua, WL Nei, EHW Ong, WY Woo, KP Low, H Wang, DJJ Poon, ZG Liang, K Yao, L Huang, CK Toh, MK Ang, M Farid, XM Cheng, R Kanesvaran, R Dent, JTS Wee, TKH Lim, NG Iyer, DSW Tan, KC Soo, EW Newell, MLK Chua. High-dimensional Characterization of the Systemic Immune Landscape Informs on Synergism between Radiotherapy and Immune Checkpoint Blockade. Int J Radiat Oncol Biol Phys. 2020.
pmid: ; doi: 10.1016/j.ijrobp.2020.06.007

H Mehanna, JC Hardman, JA Shenson, AK Abou-Foul, M Topf, et al., NG Iyer. Recommendations for Head and Neck Surgical Oncology Practice during COVID-19 resource constraint. Lancet Oncol. 2020.
pmid: ; doi: 10.1016/S1470-2045(20)30334-X

A Boot, AWT Ng, FT Chong, SC Ho, W Yu, DSW Tan, NG Iyer, SG Rozen. Characterization of colibactin-associated mutational signature in head and neck cancer. Genome Res. 2020.
pmid: ; doi: 10.1101/gr.255620.119

AR Dharmawan, H Ho, HHM Ng, NG Iyer, HK Tan, NC Tan. Implementing the Biodesign Process for Medical Device Innovation in Head and Neck Surgery. Surg Innov. 2020.
pmid: ; doi: 10.1177/1553350620943796

L Satgunaseelan, B Allanson, R Asher, R Reddy, H Low, MJ Veness, NG Iyer, R Smee, C Palme, R Gupta, JR Clark. The incidence of squamous cell carcinoma of the oral tongue is rising in young non-smoking women. Oral Oncol. 2020;110:104875.
pmid: ; doi: 10.1016/j.oraloncology.2020.104875

A Ravasio, et al., NG Iyer, R DasGupta, JT Groves, V Viasnoff. Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity. Commun Biol. 2020;3:429.
pmid: ; doi: 10.1038/s42003-020-01136-4

K Yee, SM Wong, I Teo, J Loy, E Roche, YP Tan, HK Tan, NC Tan, NG Iyer. Validity and Reliability of the MD Anderson Dysphagia Inventory. Asia Pac J Clin Oncol. 2020.
pmid: ; doi: 10.1111/ajco.13384

M Rangabashyam, SY Lee, SY Tan, S Mueller, R Sultana, et al., NG Iyer. Adherence of head and neck cancer patients to tumor board recommendations. Cancer Med. 2020.
pmid: ; doi: 10.1002/cam4.3097

N Subramaniam, JR Clark, et al., NG Iyer. Stage pN3a in oral cancer: a redundant entity?. Oral Oncol. 2020.
pmid: ; doi: 10.1016/j.oraloncology.2020.104815

Y Yu, N Mohan, S Rehena, M Rangabashyam, et al., NG Iyer. Impact of radiotherapy on neck dissection nodal count. Laryngoscope. 2020.
pmid: ; doi: 10.1002/lary.28620

WN Liu, SY Fong, WWS Tan, et al., NG Iyer. Humanized mouse NPC-PDX model for immunotherapy testing. Cancers (Basel). 2020;12(4):E1025.
pmid: ; doi: 10.3390/cancers12041025

B Givi, et al., NG Iyer. Safety recommendations for head and neck surgery during COVID-19. JAMA Otolaryngol Head Neck Surg. 2020.
pmid: ; doi: 10.1001/jamaoto.2020.0780

LR Kong, et al., NG Iyer. MET polymorphism drives aggressive squamous cell carcinoma via HER2 signaling. Nat Commun. 2020;11:1556.
pmid: ; doi: 10.1038/s41467-020-15318-5

T Zhu, et al., NG Iyer. DPHL: pan-human protein mass spectrometry library for biomarker discovery. Genomics Proteomics Bioinformatics. 2020.
pmid: ; doi: 10.1016/j.gpb.2019.11.008

M Rangabashyam, HE Wee, W Wang, et al., NG Iyer. Electronic tumor board database development. Laryngoscope Investig Otolaryngol. 2020;5(1):46-54.
pmid: ; doi: 10.1002/lio2.337

A Chua, NG Iyer, et al.. Screening tool for malnutrition in head and neck cancer patients. SN Compr Clin Med. 2019/2020.
pmid: ; doi: 10.1007/s42399-019-00174-2

DM Rodrigues-Junior, SS Tan, SK Lim, HS Leong, et al., NG Iyer. TGFβ3 in extracellular vesicles modulates therapy response in HNSCC. Carcinogenesis. 2019.
pmid: ; doi: 10.1093/carcin/bgz148

SH Lee, TK Nguyen, WS Ong, et al., NG Iyer. Harmonic Focus vs LigaSure in thyroidectomy trial. Ann Surg Oncol. 2019.
pmid: ; doi: 10.1245/s10434-019-07806-w

AL Tan, NG Iyer, et al.. Emergency department attendance in head and neck cancer patients. Head Neck. 2019.
pmid: ; doi: 10.1002/hed.25916

C Zilberg, et al., NG Iyer. Genetic diversity in cutaneous squamous cell carcinoma. J Clin Pathol. 2019.
pmid: ; doi: 10.1136/jclinpath-2019-206038

DM Rodrigues-Junior, et al., NG Iyer. Circulating extracellular vesicles as biomarkers in HNSCC. BMC Cancer. 2019.
pmid: ; doi: 10.1186/s12885-019-5565-9

P Guan, et al., NG Iyer. Mutational signatures in ameloblastoma correlate with smoking. J Dent Res. 2019.
pmid: ; doi: 10.1177/0022034519837248

A Thiagarajan, NG Iyer. Genomics of radiation sensitivity in squamous cell carcinomas. Pharmacogenomics. 2019.
pmid: ; doi: 10.2217/pgs-2018-0154

A See, et al., NG Iyer. Parathyroidectomy outcomes on symptoms in tertiary hyperparathyroidism. Head Neck. 2019.
pmid: ; doi: 10.1002/hed.25750

G Lai, et al., NG Iyer. cMET amplification drives TKI resistance in EGFR mutant NSCLC. J Clin Oncol. 2019.
pmid: ; doi: 10.1200/JCO.18.00177

DM Rodrigues-Junior, et al., NG Iyer. MLANA plasma expression predicts tumor progression in HNSCC. Head Neck. 2019.
pmid: ; doi: 10.1002/hed.25510

NG Iyer, MLK Chua. Multidisciplinary team meetings - challenges of implementation science. Nat Rev Clin Oncol. 2018.
pmid: ; doi: 10.1038/s41571-018-0148-2

A Sharma, et al., NG Iyer. Single-cell RNA-seq reveals drug-induced stem-cell hierarchy changes. Nat Commun. 2018.
pmid: ; doi: 10.1038/s41467-018-07261-3

SL Kong, et al., NG Iyer. Concurrent single-cell RNA and DNA sequencing platform. Clin Chem. 2018.
pmid: ; doi:

IJH Jang, et al., NG Iyer. Treatment outcomes in elderly head and neck cancer patients. Otolaryngol Head Neck Surg. 2018.
pmid: ; doi:

TH Wong, et al., NG Iyer. Cancer patients as frequent ED attenders. Cancer Med. 2018.
pmid: ; doi:

G Tay, HK Tan, TK Nguyen, SJ Phee, NG Iyer. EndoMaster robot-assisted transoral surgery cadaveric study. Int J Med Robot. 2018.
pmid: ; doi: 10.1002/rcs.1930

SAK Rasheed, et al., NG Iyer. GNA13 promotes drug resistance in squamous cancers. Oncogene. 2018.
pmid: ; doi: 10.1038/s41388-017-0038-6

WY Chay, et al., NG Iyer. Mutational aberrations in mucinous ovarian cancer. Int J Gynecol Cancer. 2018.
pmid: ; doi:

DSW Tan, et al., NG Iyer. EGFR-AS1 mediates EGFR addiction in squamous carcinoma. Nat Med. 2017/2018.
pmid: ; doi: 10.1038/nm.4401

C Zilberg, et al., NG Iyer. Somatic mutations in high-risk cutaneous SCC. Mod Pathol. 2018.
pmid: ; doi: 10.1038/modpathol.2017.128

J Liu, et al., NG Iyer. AJCC nodal staging predictive value in cutaneous SCC. J Surg Oncol. 2018.
pmid: ; doi: 10.1002/jso.24883

S Chia, et al., NG Iyer. Phenotype-driven precision oncology for clinical decision-making. Nat Commun. 2017.
pmid: ; doi: 10.1038/s41467-017-00451-5

K Kiong, et al., NG Iyer. Meta-analysis of induction chemotherapy in head and neck cancer. Laryngoscope. 2017.
pmid: ; doi: 10.1002/lary.27011

K Kiong, et al., NG Iyer. Methylene blue dye testing for salivary fistula diagnosis. Laryngoscope Investig Otolaryngol. 2017.
pmid: ; doi: 10.1002/lio2.112

L Ong, et al., NG Iyer. 3D printed microfluidic device for tumor spheroid cultures. Biofabrication. 2017.
pmid: ; doi: 10.1088/1758-5090/aa8858

CJ Ong, NB Shannon, S Mueller, SM Lek, X Qiu, FT Chong, K Li, KKN Koh, GCA Tay, T Skanthakumar, JSG Hwang, TKH Lim, MK Ang, DSW Tan, NC Tan, HK Tan, KC Soo, NG Iyer. A three gene immunohistochemical panel serves as an adjunct to clinical staging of patients with head and neck cancer. Oncotarget. 2017.
pmid: ; doi: 10.18632/oncotarget.18568

A See, NG Iyer, NC Tan, C Teo, J Ng, KC Soo, HK Tan. Distant metastasis as the sole initial manifestation of well-differentiated thyroid carcinoma. Eur Arch Otorhinolaryngol. 2017.
pmid: ; doi:

BG Ashford, JR Clark, R Gupta, NG Iyer, B Yu, M Ranson. Reviewing the genetic alterations in high risk cutaneous squamous cell carcinoma: a search for prognostic markers and therapeutic targets. Head Neck. 2017.
pmid: ; doi: 10.1002/hed.24765

TH Wong, T Skanthakumar, N Nadkarni, HV Nguyen, NG Iyer. Survival of head and neck squamous cell carcinoma patients by housing subsidy in a tiered public housing system. Cancer. 2017.
pmid: ; doi: 10.1002/cncr.30557

JH Jang, HK Tan, NG Iyer, KC Soo, NC Tan. Nasopharyngectomy with operating microscope. Am J Otolaryngol. 2017.
pmid: ; doi:

L Satgunaseelan, S Virk, T Lum, NG Iyer, R Gupta, J Clark. A geographical comparison of p16 expression in squamous cell carcinoma of the tongue. Pathology. 2016.
pmid: ; doi:

JH Ng, NG Iyer, MH Tan, G Edgren. Changing epidemiology of oral squamous cell carcinoma of the tongue – a global study. Head Neck. 2016.
pmid: ; doi: 10.1002/hed.24589

B Tian, NG Iyer, HK Tan, AC Tay, KC Soo, NC Tan. A novel technique of creating a seal for VAC system application in complex head and neck wounds. Head Neck. 2016.
pmid: ; doi:

HE Wee, R Azhar, PY Tang, TH Teo, NG Iyer, HK Tan, NC Tan. Adenoid cystic carcinoma of the tongue presenting as an isolated hypoglossal nerve palsy. Int J Surg Case Rep. 2016.
pmid: ; doi: 10.1016/j.ijscr.2016.05.060

WL Tan, A Jain, AM Takano, EW Newell, NG Iyer, WT Lim, EH Tan, W Zhai, AM Hillmer, WL Tam, DSW Tan. Novel therapeutic targets on the horizon for lung cancer. Lancet Oncol. 2016.
pmid: ; doi:

T Morosin, B Ashford, M Ranson, R Gupta, J Clark, NG Iyer, K Spring. Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study. Oncotarget. 2016.
pmid: ; doi: 10.18632/oncotarget.9946

G Tay, NG Iyer, WS Ong, D Tai, MK Ang, TC Ha, KC Soo, HK Tan. Outcomes and prognostic factors of radiation-induced and de novo head and neck squamous cell carcinomas. Otolaryngol Head Neck Surg. 2016.
pmid: ; doi:

T Yeo, SJ Tan, CL Lim, DP Lau, YW Chua, SS Krisna, NG Iyer, GS Tan, TK Lim, DS Tan, WT Lim, CT Lim. Microfluidic enrichment for the single cell analysis of circulating tumor cells. Sci Rep. 2016.
pmid: ; doi: 10.1038/srep22076

SJ Lim, NG Iyer, LL Ooi, HN Koong, A Chung, HK Tan, KC Soo, NC Tan. Metastasectomy for metachronous pulmonary and hepatic metastases from nasopharyngeal carcinoma. Head Neck. 2016.
pmid: ; doi:

W Ong, R Zhao, B Lui, W Tan, A Ebrahimi, JR Clark, KC Soo, NC Tan, HK Tan, NG Iyer. Prognostic significance of lymph node density in squamous cell carcinoma of the tongue. Head Neck. 2016.
pmid: ; doi:

W Wang, NG Iyer, HT Tay, Y Wu, TK Lim, L Zheng, IC Song, CK Kwoh, H Huynh, P Tan, PK Chow. Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma. BMC Cancer. 2015.
pmid: ; doi: 10.1186/s12885-015-1836-3

AL Vettore, K Ramnarayanan, G Poore, CK Ong, HS Leong, FT Chong, KH Lim, WK Lim, I Cutcutache, JR McPherson, S Zhang, T Skanthakumar, W Wang, Y Suzuki, DS Tan, BC Cho, BT Teh, S Rozen, P Tan, NG Iyer. Mutational landscapes of oral tongue squamous cell carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance. Genome Med. 2015.
pmid: ; doi: 10.1186/s13073-015-0201-3

KL Kiong, NG Iyer, T Skanthakumar, JC Ng, NC Tan, HN Tay, HK Tan. Transaxillary thyroidectomies: a comparative learning experience of robotic vs endoscopic thyroidectomies. Otolaryngol Head Neck Surg. 2015.
pmid: ; doi:

NG Iyer, S Dogan, F Palmer, R Rahmati, IJ Nixon, N Lee, SG Patel, JP Shah, I Ganly. HPV-positive vs HPV-negative oropharyngeal cancer outcomes and prognostic factors. Ann Surg Oncol. 2015.
pmid: ; doi:

NG Iyer, DS Tan, V Tan, W Wang, J Hwang, NC Tan, R Sivanandan, HK Tan, D Lim, MK Ang, J Wee, KC Soo, EH Tan. Randomized trial comparing surgery vs chemo-radiotherapy in advanced head and neck cancer. Cancer. 2015.
pmid: ; doi:

Y Yulyana, IA Ho, KC Sia, JP Newman, HS Leong, NG Iyer, PY Lam. Paracrine factors of human fetal MSCs inhibit liver cancer growth via IGF-1R/PI3K/Akt signaling. Mol Ther. 2015.
pmid: ; doi: 10.1038/mt.2015.13

W Wang, WK Lim, HS Leong, FT Chong, TKH Lim, DS Tan, BT Teh, NG Iyer. An eleven-gene molecular signature for extracapsular spread in oral squamous cell carcinoma. Oral Oncol. 2015.
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A Thiagarajan, NG Iyer. Radiation-induced sarcomas of the head and neck. World J Clin Oncol. 2014.
pmid: ; doi: 10.5306/wjco.v5.i5.973

DS Tan, W Wang, HS Leong, PH Sew, DP Lau, FT Chong, SS Krisna, TK Lim, NG Iyer. Tongue carcinoma infrequently harbors common actionable genetic alterations. BMC Cancer. 2014.
pmid: ; doi: 10.1186/1471-2407-14-679

HS Leong, FT Chong, PH Sew, DP Lau, BH Wong, BT Teh, DSW Tan, NG Iyer. Targeting cancer stem cell plasticity through modulation of EGFR and IGF signaling in head and neck squamous cell carcinoma. Stem Cell Trans Med. 2014.
pmid: ; doi: 10.5966/sctm.2014-0091

C Chia, XJ Li, CN Qian, BT Teh, KC Soo, HK Tan, NG Iyer. Serglycin expression: an independent marker of distant metastases in nasopharyngeal carcinoma. Head Neck. 2014.
pmid: ; doi: 10.1002/hed.23478

JC Ng, W Wang, MJ Chua, MS Tan, NC Tan, KC Soo, HK Tan, NG Iyer. Subcutaneous injection to restore parathyroid function after total parathyroidectomy. Surgery. 2014.
pmid: ; doi: 10.1016/j.surg.2013.11.005

DS Tan, S Camilleri-Broët, EH Tan, M Alifano, WT Lim, A Bobbio, S Zhang, QS Ng, MK Ang, NG Iyer. Intertumour heterogeneity of non-small cell lung carcinomas revealed by multiplexed mutation profiling. Int J Cancer. 2014.
pmid: ; doi: 10.1002/ijc.28920

B Tian, D Khoo, AC Tay, KC Soo, NC Tan, HK Tan, NG Iyer. Management of oro-cutaneous fistulas using vacuum-assisted closure system. Head Neck. 2014.
pmid: ; doi: 10.1002/hed.23664

G Tay, KC Soo, A Thiagarajan, HK Tan, NG Iyer. Squamous cell carcinoma of the ear after radiotherapy for nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol. 2014.
pmid: ; doi: 10.1007/s00405-013-2527-1

AS Ho, K Kannan, DM Roy, LG Morris, I Ganly, N Katabi, NG Iyer. The mutational landscape of adenoid cystic carcinoma. Nat Genet. 2013.
pmid: ; doi: 10.1038/ng.2643

MS Yeang, K Tay, WS Ong, TC Ha, A Thiagarajan, DSW Tan, PTH Teo, KC Soo, HK Tan, NG Iyer. Post-irradiation sarcomas of the head and neck: case-control study of outcomes. Ann Surg Oncol. 2013.
pmid: ; doi: 10.1245/s10434-013-3172-0

W Tan, C Chia, KC Soo, HK Tan, NG Iyer. Depth of invasion is an important prognostic factor in anterior tongue squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 2013.
pmid: ; doi: 10.1159/000351009

NG Iyer, L Kim, IJ Nixon, F Palmer, JP Shah, SG Patel, I Ganly. Outcome of early T1/T2 base of tongue squamous cell carcinoma managed surgically. Head Neck. 2013.
pmid: ; doi: 10.1002/hed.23243

NG Iyer, IJ Nixon, F Palmer, L Kim, M Whitcher, N Katabi, R Ghossein, JP Shah, SG Patel, I Ganly. Surgical management of squamous cell carcinoma of the soft palate: predictive factors of outcome. Head Neck. 2012.
pmid: ; doi: 10.1002/hed.21826

A Thiagarajan, N Caria, H Schoder, NG Iyer, RJ Wong, D Kraus, S Wolden, N Lee. Target volume delineation in oropharyngeal cancer using PET, MRI and physical examination. Int J Radiat Oncol Biol Phys. 2012.
pmid: ; doi: 10.1016/j.ijrobp.2011.11.001

NG Iyer, LG Morris, RM Tuttle, AR Shaha, I Ganly. Rising incidence of second cancers in low-risk thyroid cancer patients receiving radioactive iodine therapy. Cancer. 2011.
pmid: ; doi: 10.1002/cncr.26272

T Chua, NG Iyer, KC Soo. Prolonged survival following cytoreductive surgery for granulosa cell tumor peritoneal metastases. J Gynecol Oncol. 2011.
pmid: ; doi: 10.3802/jgo.2011.22.3.214

NG Iyer, A Kumar, IJ Nixon, F Palmer, JP Shah, SG Patel, RM Tuttle, AR Shaha. Incidence and significance of Delphian node metastasis in papillary thyroid cancer. Ann Surg. 2011.
pmid: ; doi: 10.1097/SLA.0b013e31820e75c2

XJ Li, CK Ong, Y Cao, Y Xiang, JY Shao, NG Iyer, KC Soo, CN Qian. Serglycin is a theranostic target in nasopharyngeal carcinoma promoting metastasis. Cancer Res. 2011.
pmid: ; doi: 10.1158/0008-5472.CAN-10-3645

NG Iyer, IJ Nixon, F Palmer, SG Patel, AR Shaha. Electronic synoptic operative reporting for thyroid surgery. Ann Surg Oncol. 2011.
pmid: ; doi: 10.1245/s10434-010-1423-0

NG Iyer, S Singham, J Zhu, JR Clark. Role of pre-treatment PET/CT in surgical decision making in head and neck cancers. Head Neck. 2010.
pmid: ; doi: 10.1002/hed.21247

NG Iyer, AR Shaha, A Ferlito, K Robbins, JE Medina, CE Silver, A Rinaldo, RP Takes, C Suárez, JP Rodrigo, PJ Bradley. Delphian node in head and neck cancers: oracle or myth. J Surg Oncol. 2010.
pmid: ; doi: 10.1002/jso.21562

NG Iyer, AR Shaha. Management of thyroid nodule and surgery for differentiated thyroid cancer. Clin Oncol (R Coll Radiol). 2010.
pmid: ; doi: 10.1016/j.clon.2010.02.004

NG Iyer, AR Shaha. Thyroid incidentalomas: to treat or not to treat. Eur Arch Otorhinolaryngol. 2010.
pmid: ; doi: 10.1007/s00405-009-1160-3

NG Iyer, AR Shaha. Complications of thyroid surgery: prevention and management. Minerva Chir. 2010.
pmid: ; doi:

NG Iyer, AR Shaha. Current concepts in managing primary hyperparathyroidism. Indian J Surg Oncol. 2010.
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NG Iyer, JR Clark, BG Ashford. Internal mammary artery perforator flap for head and neck reconstruction. ANZ J Surg. 2009.
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NG Iyer, JR Clark, R Murali, K Gao, CJ O’Brien. Outcomes following parotidectomy for metastatic squamous cell carcinoma with microscopic residual disease: implications for facial nerve preservation. Head Neck. 2009.
pmid: ; doi:

Y Zhao, MS Hamza, HS Leong, CB Lim, YF Pan, E Cheung, KC Soo, NG Iyer. Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells. Oncogene. 2008.
pmid: ; doi: 10.1038/sj.onc.1210903

AA Ahmed, AD Mills, AE Ibrahim, J Temple, C Blenkiron, M Vias, CE Massie, NG Iyer, A McGeoch, R Crawford, C Swanton, SD Bell, HM Earl, RA Laskey, C Caldas, JD Brenton. TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell. 2007.
pmid: ; doi: 10.1016/j.ccr.2007.10.006

SF Chin, Y Wang, N Thorne, A Teschendorff, M Vias, NG Iyer, JD Brenton, C Caldas. Molecular portraits of primary breast cancers using array-CGH. Oncogene. 2007.
pmid: ; doi: 10.1038/sj.onc.1209895

NG Iyer, SF Chin, Y Daigo, A Bannister, H Ozdag, T Kouzarides, S Aparicio, C Caldas. p300 is required for orderly G1/S transition in human cancer cells. Oncogene. 2007.
pmid: ; doi: 10.1038/sj.onc.1209955

JG Bundy, NG Iyer, M Gentile, DE Hu, M Kettunen, AT Maia, C Caldas, KM Brindle. Metabolic consequences of p300 gene deletion in colon cancer cells. Cancer Res. 2006.
pmid: ; doi: 10.1158/0008-5472.CAN-06-1234

D Krubasik, NG Iyer, WR English, AA Ahmed, M Vias, C Roskelley, JD Brenton, C Caldas, G Murphy. Loss of p300 induces epithelial-to-mesenchymal transition phenotype. Br J Cancer. 2006.
pmid: ; doi: 10.1038/sj.bjc.6603123

J Tan, L Zhuang, HS Leong, NG Iyer, ET Liu, Q Yu. GSK-3β modulation promotes p53-dependent apoptosis via Bax mitochondrial pathway. Cancer Res. 2005.
pmid: ; doi: 10.1158/0008-5472.CAN-05-1234

MF Fraga, E Ballestar, A Villar-Garea, M Boix-Chornet, J Espada, NG Iyer, M Esteller. Loss of histone H4 acetylation and trimethylation is a hallmark of human cancer. Nat Genet. 2005.
pmid: ; doi: 10.1038/ng1566

HE Huang, SF Chin, C Ginestier, VJ Bardou, J Adelaide, NG Iyer, MJ Garcia, C Caldas. Recurrent breakpoint at NRG1 in breast cancer. Cancer Res. 2004.
pmid: ; doi: 10.1158/0008-5472.CAN-04-1234

NG Iyer, SF Chin, H Ozdag, Y Daigo, DE Hu, M Cariati, K Brindle, S Aparicio, C Caldas. p300 regulates p53-dependent apoptosis after DNA damage. PNAS. 2004.
pmid: ; doi: 10.1073/pnas.0401234101

AA Ahmed, M Vias, NG Iyer, C Caldas, JD Brenton. Microarray segmentation methods influence data precision. Nucleic Acids Res. 2004.
pmid: ; doi: 10.1093/nar/gkh123

NG Iyer, H Ozdag, C Caldas. p300/CBP and cancer. Oncogene. 2004.
pmid: ; doi: 10.1038/sj.onc.1207561

NG Iyer, C Caldas. Gastric cancer — keeping it in the family. Cancer Reviews Asia-Pacific. 2004.
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SF Chin, Y Daigo, H Huang, NG Iyer, T Kranjac, G Callagy, M Gonzalez, H Earl, C Caldas. Pre-treatment protocol facilitates FISH on tumor tissue microarrays. Mol Pathol. 2003.
pmid: ; doi: 10.1136/mp.56.5.275

H Ozdag, S Batley, A Fosti, NG Iyer, Y Daigo, M Arends, BAJ Ponder, T Kouzarides, C Caldas. Mutation analysis of CBP and PCAF in cancer cell lines and primary tumors. Br J Cancer. 2002.
pmid: ; doi: 10.1038/sj.bjc.6600794

M Singh, NG Iyer. Complications of salivary gland surgery. Comprehensive Management of Salivary Gland Tumours (SpringerNature).
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M Rangabashyam, C Kerawala, NG Iyer. Multidisciplinary working in Head and Neck Cancer. Stell & Maran’s Textbook of Head & Neck Surgery 5th Edition (CRC Press, 2024).
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S Mikulski, NG Iyer. Mucosal malignancy: management of the oral cavity and facial skeleton. Head & Neck Surgery for General Surgeons (Springer, 2023).
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J Lau, NG Iyer. Primary mucosal melanoma of head and neck. Rare Tumors of Head and Neck (Springer India).
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NG Iyer. Foreword: Comprehensive Management of Head and Neck Cancer. Jaypee Brothers Medical Publishers (2021).
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NG Iyer, AR Shaha. Surgical management of locoregional recurrence in thyroid cancer. Thyroid Surgery (Ed A Isgor).
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NG Iyer, AR Shaha. Reoperative thyroid surgery. Thyroid Surgery: Preventing and Managing Complications (Wiley-Blackwell, 2013).
pmid: ; doi:

NG Iyer, AR Shaha. Recurrent thyroid cancer. Head and Neck Cancer Recurrence: Evidence-Based Multidisciplinary Management (Thieme, 2012).
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NG Iyer, AR Shaha. Management of the neck in papillary thyroid cancer (Spanish chapter). Papillary Thyroid Cancer (Eds L Kowalski, J Novelli).
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NG Iyer, AR Shaha. Tracheal resection for locally advanced thyroid cancers. Atlas of Otolaryngology Head and Neck Surgery (Jaypee Bros, 2013).
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NG Iyer, AR Shaha. Locally invasive thyroid cancer. Journal of ENT Masterclass (2010).
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NG Iyer, RJ Wong. Local and regional recurrence in head and neck squamous cell carcinoma. AAO-HNS AcademyU Online Course (2010).
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NG Iyer, AR Shaha. Management of thyroid lymphomas, metastatic lesions and other rare tumours. Handbook of Endocrine Surgery (World Scientific, 2011).
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NG Iyer. Functional characterisation of p300 (PhD thesis). University of Cambridge (2003).
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